Born in Montréal, Quebec, Canada, Bisson moved to Toronto as a teenager and there he began acting lessons; he has been acting since the age of 13. His big break was in CBC's critically acclaimed 1984 movie of the week Hockey Night with Megan Follows and Rick Moranis. He starred in the Canadian television series Learning the Ropes from 1988 to 1989. In 1994, he gained national exposure in the syndicated action series, High Tide co-starring Rick Springfield. From 2000 to 2004, he had a recurring role as attorney Brian Tedrow on the Showtime drama Soul Food. He has also starred as the F.B.I agent Jack Hudson, in the PAX TV series Sue Thomas: F.B.Eye and in the short-lived CBC drama Nothing Too Good for a Cowboy with Sarah Chalke. He appeared on Falcon Beach in season two, as well as several Lifetime cable movies, such as Crazy for Christmas, and I do (but I don't), as well as the Disney Channel movie Genius. Bisson was a guest star in the hit Canadian series "Flashpoint". He also has appeared in all of the Roxy Hunter movies, to date, as Jon. Bisson starred in the 2001 TV movie Loves Music, Loves to Dance, based on the book by Mary Higgins Clark. He provided the voice of Ferdie in the children's animated series Maxie's World.
Bisson plays the lead in the Citytv drama series Murdoch Mysteries, and made his directorial debut with the show's fourth season episode "Buffalo Shuffle".
Bisson is currently seen on a series of CIBC commercials and on their ATMs.