The first killings, a pair of gang bangers, were torn to pieces at Rainbow Beach. It appeared to be a wild animal attack, but Special Investigations was called in. The next night, a little old lady was killed in the same manner after walking past Washington Park. The next night, three bums in Burnham Park were brutally slaughtered. A month later, on the full moon, a man was killed outside a liquor store. The next night, a business man named James Harding III and his driver were killed in a parking garage. The killings stopped after the full moon ended. A new cycle began when Spike was murdered at the Varsity. He's the second victim to have a connection to Marcone, along with James Harding III.
Murphy called in the FBI because they had access to resources that she didn't. Agent Harris turned up irregularities in the bite marks; he stated that they didn't match real wolves. Believing the victims were attacked by some kind of cult using weapons edged with wolf teeth, the FBI took over the investigation and the press called them the Lobo Murders because of the wolf connection.
Through the course of his investigation, Harry discovers that the FBI agents are hexenwolves and that they are behind the Lobo murders, using them as obfuscation in their planned murder of Johnny Marcone. They began murdering peripherals to cover their tracks, framing the Streetwolves to take the blame for the mortal authorities, and Harley MacFinn to take the fall for the White Council.
Harry manages to foil their attempt to kill Johnny Marcone and destroys the wolf pelt belts they were using to transform.